Granulopoiesis

Commited granulocytic progenitors (CFU-C) generate colonies of differentiating/maturing myeloid cells in methylcellulose or agar culture. The size of their colonies is relatively small because myeloid cells die upon reaching the metamyelocyte stage. In the bone marrow metamyelocytes undergo further maturation in the marrow granulocyte reservoir before entering the blood stream as polymorphonuclear neutrophils (PMN). PMN are about equally distributed between the axial (circulating) and marginated granulocyte pools, and in health are maintained within a relatively narrow range .

Author(s): Peter R. Galbraith MD, FRCP(C)




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