by Peter R. Galbraith MD                                Last revised  May 19, 2008

Edited by Ruth S. Galbraith MD

Welcome to HemeTeam 2008

HemeTeam is a companion to hematological studies. It has been designed to facilitate self-directed learning and keeping current in hematology.   It is presented in six parts.

Part  1.  Getting started: An approach to common blood problems. (MCQs and feedback)

Part  2.  Disease mechanisms and cell biology

Part  3.  Specific diseases

Part  4.  Targeted therapy

Part  5.  Case studies 

Part  6.  Future directions in molecular diagnosis and therapy

- all chapters have been reviewed/revised in the past six months

- navigation is easier than ever

- research advances have been highlighted FYI

I hope you find this website fun and useful. I value your feedback.

NAVIGATION 

Click on an item from the list below and use your browser's back arrow if you want to return to this page.

You may freely use The QxMD Hematology calculator  BlackBerry version or Online version
which has many interesting applications.

Part 1. Getting started: An approach to common problems

Approach to the diagnosis of anemia

Approach to diagnosis of different types of anemia

- microcytic

- macrocytic

- normocytic

- hemolytic

Diagnostic blood and marrow smears

Approach to abnormal leukocyte counts

Approach to lymphadenopathy

Approach  to splenomegaly

Approach to abnormal platelet counts

Approach to abnormal Bleeding

Approach to venous thromboembolism

Approach to acute leukemia

Part 2. Disease mechanisms and cell biology

Principles of Hematopoiesis

- granulopoiesis

- lymphopoiesis

- thrombopoiesis

- apoptosis

- aplastic anemia  and pancytopenia

- angiogenesis

- endothelium

- stem cells

- telomerase

- molecular biology of acute leukemia

- biology of CML

- cell cycle 

Part 3. Specific diseases

Erythrocytes

- sickle cell disease

- iron deficiency, absorption, transport etc

- hemochromatosis

- anemia of chronic disease

Acute Leukemia

-acute lymphocytic leukemia (ALL)

-acute myelogenous leukemia (AML)

-acute promyelocytic leukemia (APL)

- prognostic Factors in AML

- minimal residual disease (MRD)

- multidrug resistance (MDR)

- stem cell transplantation (SCT) in AML

Lymphocytic neoplasms

-chronic lymphocytic leukemia (CLL)

-Hodgkin's disease

-non-Hodgkin lymphoma (NHL)

-follicular cell lymphoma (FCL)

-introduction to peripheral T-cell lymphoma (PTCL)

-multiple myeloma

-amyloidosis

Indolent stem cell neoplasms

- chronic myelogenous leukemia (CML)

- inatinib mesylate (targeted Rx for CML

- myeloproliferative disorders (MPD)

- polycythemia rubra vera (PRV)

- essential thrombocytosis (ET)

- myelofibrosis with myeloid metaplasia (MMM)

- myelodysplastic syndromes (MDS)

Hemostatic disorders

-Thrombocytopenia

- Von Willebrand's disease

-Thrombophilia

-Anti-phospholipid antibody syndrome

- Heparin induced thrombocytopenia (HIT)

-Thrombotic thrombocytopenic purpura (TTP)

Part 4. Targeted Therapy

- targeted therapy of CML

- imatinib mesylate

-antisense oligonucleotides  (anti BCL-2)

- thalidomide and Lenalidomide

- rituximab (anti CD20)

- targeted therapy of AML

- epigenetic therapies

- vascular endothelial growth factor (VEGF)

Part 5. CASE STUDIES

- microcytic anemia in a marathon runner

- anemia in a patient with a chronic disease (ACD)

- anemia in a greek woman

- unexplained macrocytosis

- fatigue and bruising in a mechanic

- pancytopenia post influenza

- ALL in a male aged 3 in 1966

- AML: 5 case studies

- APL in a Jehovah's witness

- Hodgkin's disease in a young boy

- Peripheral T - cell lymphoma- 5 cases

- Fatigue and bruising in an auto mechanic

- Vignettes- complications of polycythemia vera

- Polycythemia and ascites

- Splenomegaly in a 76 year old lawyer         

Part 6. Future Directions on Malignant Disease

- Cancer genomics

- Proteins

- Proteomics

- MicroRNAs

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Hemeteam  2008 on CD-ROM (please note system requirements)  is available on request at a cost of $ 30 which includes shipping and handling. This may be of interest to students with limited online access.  Please submit your order by clicking on the PayPal link at the side of this page.  Allow 2 days for the disk to be burned and mailed.

CD-ROMs are burned only when a request is received. Multiple copies may be obtained at a reduced rate by contacting the author directly at galraip@queensu.ca.